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A dengue monovalent vaccine with novel structure provides cross-protection against four serotypes of dengue virus

2018-03-05

Abstract excerpt

Dengue fever is caused by four different serotypes of dengue virus (DENV) which is the leading cause of worldwide arboviral diseases in humans. The vaccine candidates under development require a tetravalent immunogen to induce a balanced immunity against all four serotypes of dengue virus. Herein we show that mice vaccinated with highly matured virus-like particles derived from DENV serotype 2 (mD2VLP) can generat...

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Identifiers and source

Literature Corpus work
06cf1e46-6218-5990-92c1-815f995a27e7
DOI
10.1101/275685
Open publication

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