Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antigenic Variation of the Dengue Virus 2 Genotypes Impacts the Neutralization Activity of Human Antibodies in Vaccinees.

Cell reports - 6 Oct 2020

Martinez David R, Yount Boyd, Nivarthi Usha, Munt Jennifer E, Delacruz Matthew J, Whitehead Stephen S, Durbin Anna P, de Silva Aravinda M, Baric Ralph S

Abstract excerpt

Dengue virus (DENV) infects an estimated 390 million people each year worldwide. As tetravalent DENV vaccines have variable efficacy against DENV serotype 2 (DENV2), we evaluated the role of genetic diversity within the pre-membrane (prM) and envelope (E) proteins of DENV2 on vaccine performance. We generated a recombinant DENV2 genotype variant panel with contemporary prM and E isolates that are representative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to Antigenic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dengue Virus

Share to Genotype

Share to Malaria Research and Control

Share to Mosquito-borne diseases and control

Share to Vaccination

Share to Viral Infections and Vectors

Source

Open in PubMed Open full text

Identifiers

PMID: 33027653
DOI: 10.1016/j.celrep.2020.108226
PMCID: PMC7583086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antigenic Variation of the Dengue Virus 2 Genotypes Impacts the Neutralization Activity of Human Antibodies in Vaccinees.PMID 33027653Read ↗

Genetic Variation between Dengue Virus Type 4 Strains Impacts Human Antibody Binding and Neutralization.Semantic proximity Read ↗

Dengue Virus Serotype 1 Conformational Dynamics Confers Virus Strain-Dependent Patterns of Neutralization by Polyclonal Sera.Semantic proximity Read ↗

Genetic epidemiology of dengue viruses in phase III trials of the CYD tetravalent dengue vaccine and implications for efficacy.Semantic proximity Read ↗

Dengue antigenic relationships predict evolutionary dynamicsSemantic proximity Read ↗

Conservation of the DENV-2 type-specific and DEN complex-reactive antigenic sites among DENV-2 genotypes.Semantic proximity Read ↗

Stabilized dengue virus 2 envelope subunit vaccine redirects the neutralizing antibody response to all E-domainsSemantic proximity Read ↗

Stabilized dengue virus 2 envelope subunit vaccine redirects the neutralizing antibody response to all E-domainsSemantic proximity Read ↗

Dengue Virus Type 2: Global Epidemiology, Molecular Evolution, and Immune Response InsightsSemantic proximity Read ↗

Virus-like particle secretion and genotype-dependent immunogenicity of dengue virus serotype 2 DNA vaccine.Semantic proximity Read ↗

Development and characterization of a reverse genetic system for studying dengue virus serotype 3 strain variation and neutralization.Semantic proximity Read ↗

Genetic diversity of the Chikungunya virus E2 gene may have implications for the design of vaccines and therapeutic antibodies.Semantic proximity Read ↗

A dengue monovalent vaccine with novel structure provides cross-protection against four serotypes of dengue virusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.