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An epitope-resurfaced virus-like particle can induce broad neutralizing antibody against four serotypes of dengue virus

2018-06-20

Abstract excerpt

Dengue fever is caused by four different serotypes of dengue virus (DENV) which is the leading cause of worldwide arboviral diseases in humans. Virus-like particles (VLPs) containing flavivirus prM/E proteins have been demonstrated to be a potential vaccine candidate; however, the structure of dengue VLP is poorly understood. Herein we show for the first time that mD2VLP particles possess a T=1 icosahedral symmetr...

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Identifiers and source

Literature Corpus work
01727a37-41fa-58e6-bcc6-87c671d012d3
DOI
10.1101/351700
Open publication

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