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Oligomeric state of the ZIKV E protein defines protective immune responses

2019-06-18

Abstract excerpt

The current leading Zika vaccine candidates in clinical testing are based on live or killed virus platforms, which have safety issues, especially in pregnant women. Zika subunit vaccines, however, have shown poor performance in preclinical studies. We hypothesized that Zika Envelope (E) protein subunit vaccines have performed poorly because the antigens tested have been recombinant E monomers that do not display c...

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Identifiers and source

Literature Corpus work
44f6dec6-0445-5836-98eb-c5eb8cb4fa85
DOI
10.1101/674424
Open publication

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Oligomeric state of the ZIKV E protein defines protective immune responsesDOI 10.1101/674424
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