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Epitope resurfacing on dengue virus-like particle vaccine preparation to induce broad neutralizing antibody

18 Oct 2018

Abstract excerpt

Dengue fever is caused by four different serotypes of dengue virus (DENV) which is the leading cause of worldwide arboviral diseases in humans. Virus-like particles (VLPs) containing flavivirus prM/E proteins have been demonstrated to be a potential vaccine candidate; however, the structure of dengue VLP is poorly understood. Herein VLP derived from DENV serotype-2 were engineered becoming highly matured (mD2VLP)...

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PMID: 30334522
DOI: 10.7554/elife.38970

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