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Article

A conserved set of mutations for stabilizing soluble envelope protein dimers from dengue and Zika viruses to advance the development of subunit vaccines.

The Journal of biological chemistry - 1 Jul 2022

Phan Thanh T N, Hvasta Matthew G, Kudlacek Stephan T, Thiono Devina J, Tripathy Ashutosh, Nicely Nathan I, de Silva Aravinda M, Kuhlman Brian

Abstract excerpt

Dengue viruses (DENV serotypes 1-4) and Zika virus (ZIKV) are related flaviviruses that continue to be a public health concern, infecting hundreds of millions of people annually. The traditional live-attenuated virus vaccine approach has been challenging for the four DENV serotypes because of the need to achieve balanced replication of four independent vaccine components. Subunit vaccines represent an alternative...

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Identifiers

PMID: 35643320
DOI: 10.1016/j.jbc.2022.102079
PMCID: PMC9249817

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