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Article

Dimerization of Dengue Virus E Subunits Impacts Antibody Function and Domain Focus

30 Jun 2020

Abstract excerpt

Dengue virus vaccine development is particularly challenging because vaccines have to provide protection against four different dengue virus stereotypes. The leading dengue virus vaccine candidates in clinical testing are all based on live-virus vaccine platforms and struggle to induce balanced immunity. Envelope subunit antigens have the potential to overcome these limitations but have historically performed...

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Identifiers

PMID: 32611757
DOI: 10.1128/jvi.00745-20

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