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Article

Evolution of a Functionally Intact but Antigenically Distinct DENV Fusion Loop

2023-03-27

Abstract excerpt

<h4>ABSTRACT</h4> A hallmark of Dengue virus (DENV) pathogenesis is the potential for antibody-dependent enhancement, which is associated with deadly DENV secondary infection, complicates the identification of correlates of protection, and negatively impacts the safety and efficacy of DENV vaccines. ADE is linked to antibodies targeting the fusion loop (FL) motif of the envelope protein, which is completely conse...

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Identifiers and source

Literature Corpus work
c17442cb-fb75-595a-9c9b-f89d642ac10a
DOI
10.1101/2023.03.22.533803
Open publication

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Evolution of a Functionally Intact but Antigenically Distinct DENV Fusion LoopDOI 10.1101/2023.03.22.533803
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