Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines

11 May 2021

Abstract excerpt

Abstract Ebola virus (EBOV) glycoprotein (GP) can be recognized by neutralizing antibodies (NAbs) and is the main target for vaccine design. Here, we first investigate the contribution of the stalk and heptad repeat 1-C (HR1 C ) regions to GP metastability. Specific stalk and HR1 C modifications in a mucin-deleted form (GPΔmuc) increase trimer yield, whereas alterations of HR1 C exert a more complex effect on...

Source

Identifiers

PMID: 33976149
DOI: 10.1038/s41467-021-22867-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccinesPMID 33976149Read ↗

Rational design of next-generation filovirus vaccines through glycoprotein stabilization, nanoparticle display, and glycan modificationSemantic proximity Read ↗

Design of universal Ebola virus vaccine candidates <i>via</i> immunofocusingSemantic proximity Read ↗

Rational Design of Multiclade Coronavirus Spike Immunodominant Domain Nanoparticles to Elicit Broad Antibody ResponsesSemantic proximity Read ↗

Design of universal Ebola virus vaccine candidates via immunofocusingSemantic proximity Read ↗

Virus-like particles: flexible platforms for vaccine developmentSemantic proximity Read ↗

Prefusion-Stabilized Lassa Virus Trimer Identifies Neutralizing Nanobodies and Reveals an Apex-Situated Site of VulnerabilitySemantic proximity Read ↗

Stabilized dengue virus 2 envelope subunit vaccine redirects the neutralizing antibody response to all E-domainsSemantic proximity Read ↗

Stabilized dengue virus 2 envelope subunit vaccine redirects the neutralizing antibody response to all E-domainsSemantic proximity Read ↗

Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriersSemantic proximity Read ↗

Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticlesSemantic proximity Read ↗

Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.Semantic proximity Read ↗

Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.