Rational design of flavivirus E protein vaccine optimizes immunogenicity and mitigates antibody dependent enhancement risk.

doi:10.1038/s41467-025-67447-4

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Article

Rational design of flavivirus E protein vaccine optimizes immunogenicity and mitigates antibody dependent enhancement risk.

Nature communications - 22 Dec 2025

Wang Yimeng, Galkin Andrey, Shang Xiaoran, Marin Alexander, Jin Shaohua, Ye Ting-Juan, Bale Shridhar, Chiang Chi-I, Chowdhury Ananda, Chenine Agnes L, Turonis Ashley, Greenhouse Jack, Stone Rebecca, Wear Jaclyn, Kar Swagata, Andersen Hanne, Huang Yan-Jang S, Vanlandingham Dana L, Higgs Stephen, Lapidus Rena G, Fuerst Thomas, Weber David J, Wyatt Richard T, Iffland Christel, Pierson Theodore C, Andrianov Alexander K, Pozharski Edwin, Li Yuxing

Abstract excerpt

Flaviviruses are a family of related viruses that cause substantial global morbidity and mortality. Vaccination against one flavivirus can sometimes exacerbate disease caused by related viruses through antibody-dependent enhancement (ADE) or interfere with the efficacy of subsequent vaccines. To address this challenge, we develop a vaccine strategy by introducing G5C/G102C mutations into the flavivirus envelope...

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Identifiers

PMID: 41429771
DOI: 10.1038/s41467-025-67447-4
PMCID: PMC12748774

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