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Article

Enhanced Neuronal Activity and Asynchronous Calcium Transients Revealed in a 3D Organoid Model of Alzheimer’s Disease

2020-07-08

Abstract excerpt

Advances in the development of three-dimensional (3D) brain organoids maintained in vitro have provided excellent opportunities to study brain development and neurodegenerative disorders, including Alzheimer’s disease (AD). However, there remains a need to generate AD organoids bearing patient-specific genomic backgrounds that can functionally recapitulate key features observed in the AD patient’s brain. To addre...

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Literature Corpus work
348305df-ef1c-542d-bd95-253ba24a1d0a
DOI
10.1101/2020.07.07.192781
Open publication

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Enhanced Neuronal Activity and Asynchronous Calcium Transients Revealed in a 3D Organoid Model of Alzheimer’s DiseaseDOI 10.1101/2020.07.07.192781
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