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Patient-Derived <i>PSEN1</i> Cerebral Organoids Revealed Parallel Development of Amyloid-β Accumulation and Network Dysfunction

2026-04-06

Abstract excerpt

Alzheimer’s disease (AD) is a neurodegenerative disorder characterised by progressive dementia, brain atrophy, and ultimately death. Using cerebral organoids derived from human induced pluripotent stem cells (hiPSCs) carrying the familial PSEN1 A246E variant, we investigated the temporal relationship between amyloid-β (Aβ) dysregulation and spontaneous neuronal activity. Multielectrode array recordings from the d...

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Literature Corpus work
94594c4e-3b45-5353-ac6f-71217d5548f0
DOI
10.64898/2026.04.02.707990
Open publication

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