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Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development.

Cell reports - 28 Nov 2023

Vanova Tereza, Sedmik Jiri, Raska Jan, Amruz Cerna Katerina, Taus Petr, Pospisilova Veronika, Nezvedova Marketa, Fedorova Veronika, Kadakova Sona, Klimova Hana, Capandova Michaela, Orviska Petra, Fojtik Petr, Bartova Simona, Plevova Karla, Spacil Zdenek, Hribkova Hana, Bohaciakova Dasa

Abstract excerpt

During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used to study human neural development and disease. Especially in the field of Alzheimer's disease (AD), remarkable effort has been put into investigating molecular mechanisms behind this disease. Then, with the advent of 3D neuronal cultures and cerebral organoids (COs), several studies have demonstrated that this model can...

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PMID: 37864790
DOI: 10.1016/j.celrep.2023.113310

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