Article

Autophagy activators normalize aberrant Tau proteostasis and rescue synapses in human familial Alzheimer’s disease iPSC-derived cortical organoids

2025-06-25

Abstract excerpt

<h4>SUMMARY</h4> Alzheimer’s disease (AD) is the most common form of dementia worldwide. Despite extensive progress, the cellular and molecular mechanisms of AD remain incompletely understood, partially due to inadequate disease models. To illuminate the earliest changes in hereditary (familial) Alzheimer’s disease, we developed an isogenic AD cerebrocortical organoid (CO) model. Our refined methodology produces...

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Literature Corpus work: 52d9a8a5-7cfe-5ba9-8ee2-4b44bc4d101c
DOI: 10.1101/2025.06.25.661453

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