Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Familial Alzheimer's disease-associated PSEN1 mutations affect neurodevelopment through increased Notch signaling.

Stem cell reports - 11 Jul 2023

Hurley Erin M, Mozolewski Pawel, Dobrowolski Radek, Hsieh Jenny

Abstract excerpt

Alzheimer's disease (AD) is the most common neurodegenerative disorder, but its root cause may lie in neurodevelopment. PSEN1 mutations cause the majority of familial AD, potentially by disrupting proper Notch signaling, causing early unnoticed cellular changes that affect later AD progression. While rodent models are useful for modeling later stages of AD, human induced pluripotent stem cell-derived cortical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Alzheimer's disease research and treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Peptides

Share to Induced Pluripotent Stem Cells

Share to Mutation

Share to Neurons

Share to Pluripotent Stem Cells Research

Share to Presenilin-1

Source

Open in PubMed Open full text

Identifiers

PMID: 37352850
DOI: 10.1016/j.stemcr.2023.05.018
PMCID: PMC10362499

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Familial Alzheimer's disease-associated PSEN1 mutations affect neurodevelopment through increased Notch signaling.PMID 37352850Read ↗

Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis.Semantic proximity Read ↗

Induced Pluripotent Stem Cells from Familial Alzheimer's Disease Patients Differentiate into Mature Neurons with Amyloidogenic PropertiesSemantic proximity Read ↗

Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development.Semantic proximity Read ↗

Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors.Semantic proximity Read ↗

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes.Semantic proximity Read ↗

Alzheimer’s Disease Mutations Disrupt Neural Stem Cell Fate and Early Brain DevelopmentSemantic proximity Read ↗

Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations.Semantic proximity Read ↗

Autophagy activators normalize aberrant Tau proteostasis and rescue synapses in human familial Alzheimer’s disease iPSC-derived cortical organoidsSemantic proximity Read ↗

Simple modeling of familial Alzheimer’s disease using human pluripotent stem cell-derived cerebral organoid technologySemantic proximity Read ↗

Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies.Semantic proximity Read ↗

Modeling familial Alzheimer's disease with induced pluripotent stem cells.Semantic proximity Read ↗

Enhanced Neuronal Activity and Asynchronous Calcium Transients Revealed in a 3D Organoid Model of Alzheimer’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.