Article

Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions

2017-08-17

Abstract excerpt

<h4>ABSTRACT</h4> The APOBEC3 (A3) family of human cytidine deaminases is renowned for providing a first line of defense against many exogenous and endogenous retroviruses. However, the ability of these proteins to deaminate deoxycytidines in ssDNA makes A3s a double-edged sword. When overexpressed, A3s can mutate endogenous genomic DNA resulting in a variety of cancers. Although the sequence context for mutating...

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Literature Corpus work: 34247185-88a3-5a55-8cca-b83e5081b510
DOI: 10.1101/176297

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