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Article

Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions.

Scientific reports - 14 May 2018

Silvas Tania V, Hou Shurong, Myint Wazo, Nalivaika Ellen, Somasundaran Mohan, Kelch Brian A, Matsuo Hiroshi, Kurt Yilmaz Nese, Schiffer Celia A

Abstract excerpt

The APOBEC3 (A3) family of human cytidine deaminases is renowned for providing a first line of defense against many exogenous and endogenous retroviruses. However, the ability of these proteins to deaminate deoxycytidines in ssDNA makes A3s a double-edged sword. When overexpressed, A3s can mutate endogenous genomic DNA resulting in a variety of cancers. Although the sequence context for mutating DNA varies among...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29760455
DOI: 10.1038/s41598-018-25881-z
PMCID: PMC5951847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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