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Article

Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s.

The Journal of biological chemistry - 1 Aug 2021

Hou Shurong, Lee Jeong Min, Myint Wazo, Matsuo Hiroshi, Kurt Yilmaz Nese, Schiffer Celia A

Abstract excerpt

The human cytidine deaminase family of APOBEC3s (A3s) plays critical roles in both innate immunity and the development of cancers. A3s comprise seven functionally overlapping but distinct members that can be exploited as nucleotide base editors for treating genetic diseases. Although overall structurally similar, A3s have vastly varying deamination activity and substrate preferences. Recent crystal structures of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34171358
DOI: 10.1016/j.jbc.2021.100909
PMCID: PMC8313598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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