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Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure

3 Dec 2019

Abstract excerpt

The human apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (APOBEC3, A3) family member proteins can deaminate cytosines in single-strand (ss) DNA, which restricts human immunodeficiency virus type 1 (HIV-1), retrotransposons, and other viruses such as hepatitis B virus, but can cause a mutator phenotype in many cancers. While structural information exists for several A3 proteins, the precise...

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PMID: 31943071
DOI: 10.1093/nar/gkz1164

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