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Article

Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies.

PloS one - 1 Jan 2018

Ziegler Samantha J, Liu Chang, Landau Mark, Buzovetsky Olga, Desimmie Belete A, Zhao Qi, Sasaki Tomoaki, Burdick Ryan C, Pathak Vinay K, Anderson Karen S, Xiong Yong

Abstract excerpt

Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3 (A3) proteins are a family of cytidine deaminases that catalyze the conversion of deoxycytidine (dC) to deoxyuridine (dU) in single-stranded DNA (ssDNA). A3 proteins act in the innate immune response to viral infection by mutating the viral ssDNA. One of the most well-studied human A3 family members is A3G, which is a potent inhibitor of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29596531
DOI: 10.1371/journal.pone.0195048
PMCID: PMC5875850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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