Article
Understanding the Structure, Multimerization, Subcellular Localization and mC Selectivity of a Genomic Mutator and Anti-HIV Factor APOBEC3H.
Scientific reports - 28 Feb 2018
Ito Fumiaki, Yang Hanjing, Xiao Xiao, Li Shu-Xing, Wolfe Aaron, Zirkle Brett, Arutiunian Vagan, Chen Xiaojiang S
Abstract excerpt
APOBEC3H (A3H) is a member of the APOBEC3 subfamily of DNA cytosine deaminases that are important for innate immune defense and have been implicated in cancer biogenesis. To understand the structural basis for A3H biochemical function, we determined a high-resolution structure of human A3H and performed extensive biochemical analysis. The 2.49 Å crystal structure reveals a uniquely long C-terminal helix 6 (h6), a...
Topics
- 5-Methylcytosine
- Aminohydrolases
- Genomics
- HEK293 Cells
- HIV
- Humans
- Immunity, Innate
- Intracellular Space
- Models, Molecular
- Mutation
- Protein Multimerization
- Protein Transport
- Substrate Specificity