Article
An extended APOBEC3A mutation signature in cancer.
Nature communications - 11 Mar 2021
Langenbucher Adam, Bowen Danae, Sakhtemani Ramin, Bournique Elodie, Wise Jillian F, Zou Lee, Bhagwat Ashok S, Buisson Rémi, Lawrence Michael S
Abstract excerpt
APOBEC mutagenesis, a major driver of cancer evolution, is known for targeting TpC sites in DNA. Recently, we showed that APOBEC3A (A3A) targets DNA hairpin loops. Here, we show that DNA secondary structure is in fact an orthogonal influence on A3A substrate optimality and, surprisingly, can override the TpC sequence preference. VpC (non-TpC) sites in optimal hairpins can outperform TpC sites as mutational...
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