Article
The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization.
Structure (London, England : 1993) - 5 May 2015
Bohn Markus-Frederik, Shandilya Shivender M D, Silvas Tania V, Nalivaika Ellen A, Kouno Takahide, Kelch Brian A, Ryder Sean P, Kurt-Yilmaz Nese, Somasundaran Mohan, Schiffer Celia A
Abstract excerpt
Deaminase activity mediated by the human APOBEC3 family of proteins contributes to genomic instability and cancer. APOBEC3A is by far the most active in this family and can cause rapid cell death when overexpressed, but in general how the activity of APOBEC3s is regulated on a molecular level is unclear. In this study, the biochemical and structural basis of APOBEC3A substrate binding and specificity is...
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