Article

Structural analysis of the active site and DNA binding of human cytidine deaminase APOBEC3B

2018-04-18

Abstract excerpt

APOBEC3s proteins (A3s), a family of human cytidine deaminases, protect the host cell from endogenous retro-elements and exogenous viral infections by introducing hypermutations. However, the ability to mutate genomic DNA makes A3s a potential cancer source. Of the 7 human A3s, A3B has been implicated as an endogenous cause for multiple cancers. Despite overall similarity, A3s have distinct deamination activity wi...

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Literature Corpus work: 75b00f3d-a4ee-5368-8857-acbb52392761
DOI: 10.1101/304170

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