Article

Skipping and sliding to optimize target search on protein-bound DNA and RNA

2020-06-05

Abstract excerpt

Rapidly finding a specific nucleic-acid sequences in a large pool of competing off-targets is a fundamental challenge overcome by all living systems. To optimize the search and beat the diffusion limit, it is known that searchers should spend time sliding along the nucleic-acid substrate. Still, such sliding generally has to contend with high levels of molecular crowding on the substrate, and it remains unclear wh...

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Identifiers and source

Literature Corpus work: 335ead32-0069-5b10-9e54-78fb24214864
DOI: 10.1101/2020.06.04.133629

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