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Article

Clutch mechanism of chemomechanical coupling in a DNA resecting motor nuclease.

Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2021

Unciuleac Mihaela-Carmen, Meir Aviv, Xue Chaoyou, Warren Garrett M, Greene Eric C, Shuman Stewart

Abstract excerpt

Mycobacterial AdnAB is a heterodimeric helicase-nuclease that initiates homologous recombination by resecting DNA double-strand breaks (DSBs). The N-terminal motor domain of the AdnB subunit hydrolyzes ATP to drive rapid and processive 3' to 5' translocation of AdnAB on the tracking DNA strand. ATP hydrolysis is mechanically productive when oscillating protein domain motions synchronized with the ATPase cycle...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33836607
DOI: 10.1073/pnas.2023955118
PMCID: PMC7980473

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