Article
A single-molecule characterization of p53 search on DNA.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jan 2011
Tafvizi Anahita, Huang Fang, Fersht Alan R, Mirny Leonid A, van Oijen Antoine M
Abstract excerpt
The tumor suppressor p53 slides along DNA while searching for its cognate site. Central to this process is the basic C-terminal domain, whose regulatory role and its coordination with the core DNA-binding domain is highly debated. Here we use single-molecule techniques to characterize the search process and disentangle the roles played by these two DNA-binding domains in the search process. We demonstrate that...
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