Article

A Dynamic Search Mechanism Enables APE1 to Identify AP-Sites in DNA

2026-01-06

Abstract excerpt

Apurinic/apyrimidinic (AP) sites are among the most frequent DNA lesions, arising thousands of times per cell each day. These AP-sites threaten genomic stability and, if left unrepaired, can lead to mutagenesis and human disease. The essential base excision repair enzyme Apurinic/Apyrimidinic Endonuclease I (APE1) initiates repair by cleaving DNA at AP-sites, yet how APE1 efficiently locates and recognizes these l...

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Literature Corpus work: 3f6c17a6-da53-5620-a967-2540c8c6d9b8
DOI: 10.64898/2026.01.06.697944

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