Article

Loops are Geometric Catalysts for DNA Integration

2023-06-22

Abstract excerpt

The insertion of HIV and other DNA elements within genomes underpins both genetic diversity and disease when unregulated. Most of these insertions are not random and occupy specific positions within the genome but the physical mechanisms underlying the integration site selection are poorly understood. Here we perform Molecular Dynamics simulations to study the insertion of DNA elements, such as HIV viral DNA or tr...

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Literature Corpus work: aff2ceb6-831f-57b8-8104-f27f7b01109c
DOI: 10.1101/2023.06.21.545982

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