RNA polymerase approaches its promoter without long-range sliding along DNA.

Abstract excerpt

Sequence-specific DNA binding proteins must quickly bind target sequences, despite the enormously larger amount of nontarget DNA present in cells. RNA polymerases (or associated general transcription factors) are hypothesized to reach promoter sequences by facilitated diffusion (FD). In FD, a protein first binds to nontarget DNA and then reaches the target by a 1D sliding search. We tested whether Escherichia...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Diffusion
• Share to DNA, Bacterial
• Share to Escherichia coli