Article
Metabolic polygenic risk scores for prediction of obesity, type 2 diabetes, and related morbidities.
Cell metabolism - 5 May 2026
Kim Min Seo, Chen Qiuli, Sui Yang, Yang Xiong, Wang Shaoqi, Weng Lu-Chen, Cho So Mi Jemma, Koyama Satoshi, Zhu Xinyu, Yu Kang, Chen Xingyu, Zhang Rufan, Yin Wanqing, Liao Shuangqiao, Liu Zhaoqi, Alkuraya Fowzan S, Natarajan Pradeep, Ellinor Patrick T, Fahed Akl C, Wang Minxian
Abstract excerpt
Obesity and type 2 diabetes (T2D) are metabolic diseases with shared pathophysiology. Traditional polygenic risk scores (PRSs) have focused on these conditions individually, yet the single-disease approach falls short in capturing the full dimension of metabolic dysfunction. We derived a biologically enriched metabolic PRS (MetPRS), a composite score that uses multi-ancestry genome-wide association studies of 20...
Topics
- Diabetes Mellitus, Type 2
- Humans
- Genetic Risk Score
- Obesity
- Genome-Wide Association Study
- Genetic Predisposition to Disease
- Multifactorial Inheritance
- Risk Factors