Article

Metabolic Polygenic Risk Scores for Prediction of Obesity, Type 2 Diabetes, and Related Morbidities

2024-11-04

Abstract excerpt

Obesity and type 2 diabetes (T2D) are metabolic diseases with shared pathophysiology. Traditional polygenic risk scores (PRS) have focused on these conditions individually, yet the single disease approach falls short in capturing the full dimension of metabolic dysfunction. We derived biologically enriched metabolic PRS (MetPRS), a composite score that uses multi-ancestry genome-wide association studies of 22 meta...

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Literature Corpus work: 0d258b6f-ecfb-5b41-8196-1026edb25aad
DOI: 10.1101/2024.11.01.24316620

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