Article

Type 2 diabetes polygenic risk score demonstrates context-dependent effects and associations with type 2 diabetes-related risk factors and complications across diverse populations

2025-02-20

Abstract excerpt

Polygenic risk scores (PRS) hold prognostic value for identifying individuals at higher risk of type 2 diabetes (T2D). However, further characterization is needed to understand the generalizability of T2D PRS in diverse populations across various contexts. We characterized a multi-ancestry T2D PRS among 244,637 cases and 637,891 controls across eight populations from the Population Architecture Genomics and Epidem...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 11c5ced1-99ed-5a0f-a4fd-6460eaeb528e
DOI: 10.1101/2025.02.15.25322341

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Type 2 diabetes polygenic risk score demonstrates context-dependent effects and associations with type 2 diabetes-related risk factors and complications across diverse populationsDOI 10.1101/2025.02.15.25322341Read

Polygenic risk score for type 2 diabetes shows context-dependent effects across populations.Semantic proximity Read

Improving type 2 diabetes polygenic risk scores by incorporating rare, low-frequency, and population-specific variantsSemantic proximity Read

Integrated clinical risk prediction of type 2 diabetes with a multifactorial polygenic risk scoreSemantic proximity Read

Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries.Semantic proximity Read

Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation.Semantic proximity Read

Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score.Semantic proximity Read

Standardized Measurement of Type 1 Diabetes Polygenic Risk Across Multi-Ancestry Population CohortsSemantic proximity Read

Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic ScoreSemantic proximity Read

Could personalised risk prediction for type 2 diabetes using polygenic risk scores direct prevention, enhance diagnostics, or improve treatment?Semantic proximity Read

Validation of a Trans-Ancestry Polygenic Risk Score for Type 2 Diabetes in Diverse PopulationsSemantic proximity Read

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.Semantic proximity Read

Polygenic Scores for Longitudinal Prediction of Incident Type 2 Diabetes in an Ancestrally and Medically Diverse Primary Care NetworkSemantic proximity Read