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Article

Large-scale multi-omics enhance risk prediction for type 2 diabetes.

Cardiovascular diabetology - 28 May 2026

Xie Ruijie, Herder Christian, Schöttker Ben

Abstract excerpt

BACKGROUND: Polygenic risk scores (PRS), metabolomics, and proteomics have each shown promise in improving type 2 diabetes risk prediction, but their combined utility beyond established clinical models remains unclear. We aimed to evaluate whether integrating multi-omics biomarkers enhances 10-year type 2 diabetes risk prediction beyond single-omics extensions and the clinical Cambridge Diabetes Risk Score...

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Identifiers

PMID: 42210368
DOI: 10.1186/s12933-026-03223-y
PMCID: PMC13217982

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