Article

Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases

2019-12-19

Abstract excerpt

<h4>Summary Paragraph</h4> Common human diseases are frequently polygenic in architecture, comprising a large number of risk alleles with small effects spread across the genome 1–3 . Polygenic scores (PGSs) aggregate these alleles into a metric which represents an individual’s genetic predisposition to a specific disease. PGSs have shown promise for early risk prediction 4–7 , and there is potential to use PGSs...

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Literature Corpus work: 1b7148af-c501-5272-885a-98a5be527de1
DOI: 10.1101/2019.12.14.876474

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