Article

Structural basis of human Nav1.5 gating mechanisms

2024-04-11

Abstract excerpt

<title>Abstract</title> <p>Voltage-gated Na<sub>v</sub>1.5 channels are central to the generation and propagation of cardiac action potentials<sup>1</sup>. Aberrations in their function are associated with a wide spectrum of cardiac diseases including arrhythmias and heart failure<sup>2-5</sup>. Despite decades of progress in Na<sub>v</sub>1.5 biology<sup>6-8</sup>, the lack of structural insights into intracellu...

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Literature Corpus work: 1f4712f3-0794-5ef5-b759-93f76bf13a8b
DOI: 10.21203/rs.3.rs-3985999/v1

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