Article

Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain

2021-09-09

Abstract excerpt

<title>Abstract</title> <p>Kv3 channels have distinctive gating kinetics tailored for rapid repolarization in fast-spiking neurons. Malfunction of this process due to genetic variants in the <italic>KCNC1</italic> gene causes severe epileptic disorders, yet the structural determinants for the unusual gating properties remain elusive. Here, we present cryo-EM structures of the human Kv3.1a channel, revealing a uni...

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Literature Corpus work: 3f2ef8dd-f344-5aca-88ea-5139bed35109
DOI: 10.21203/rs.3.rs-828003/v1

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