Article

Human thymopoiesis produces polyspecific CD8 <sup>+</sup> α/β T cells responding to multiple viral antigens

2020-07-29

Abstract excerpt

T cell receptors (TCRs) are formed by stochastic gene rearrangements, theoretically generating >10 19 sequences. They are selected during thymopoiesis, which releases a repertoire of about 10 8 unique TCRs per individual. How evolution shaped a process that produces TCRs that can effectively handle a countless and evolving set of infectious agents is a central question of immunology. The paradigm is that a diver...

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Literature Corpus work: 330d4a12-9acf-552f-afd5-4f0354e8e04d
DOI: 10.1101/2020.07.27.223354

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