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Longitudinal analysis reveals age-related changes in the T cell receptor repertoire of human T cell subsets

16 Jun 2022

Abstract excerpt

A diverse T cell receptor (TCR) repertoire is essential for protection against a variety of pathogens, and TCR repertoire size is believed to decline with age. However, the precise size of human TCR repertoires, in both total and subsets of T cells, as well as their changes with age, are not fully characterized. We conducted a longitudinal analysis of the human blood TCRα and TCRβ repertoire of CD4+ and CD8+ T...

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PMID: 35708913
DOI: 10.1172/jci158122

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