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Human thymopoiesis produces polyspecific CD8+ α/β T cells responding to multiple viral antigens

13 Feb 2023

Abstract excerpt

T-cell receptors (TCRs) are formed by stochastic gene rearrangements, theoretically generating >10 19 sequences. They are selected during thymopoiesis, which releases a repertoire of about 10 8 unique TCRs per individual. How evolution shaped a process that produces TCRs that can effectively handle a countless and evolving set of infectious agents is a central question of immunology. The paradigm is that a...

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PMID: 36995951
DOI: 10.7554/elife.81274

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