Article

T-cell receptor <i>αβ</i> chain pairing is associated with CD4 <sup>+</sup> and CD8 <sup>+</sup> lineage specification

2018-04-03

Abstract excerpt

While a highly diverse T-cell receptor (TCR) repertoire is the hallmark of a healthy adaptive immune system, relatively little is understood about how the CD4 + and CD8 + TCR repertoires differ from one another. We here utilize high-throughput single T-cell sequencing to obtain approximately 100,000 TCR αβ chain pairs from human subjects, stratified into CD4 + and CD8 + lineages. We reveal that substantial in...

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Literature Corpus work: 02ce7e39-f003-5e00-84b1-e68959800a51
DOI: 10.1101/293852

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