Article

Polyspecific CD8+ α/βT-Cells that Respond to Multiple Viruses and Drive COVID-19 Outcome

2020-12-09

Abstract excerpt

Randomly generated T cell receptors (TCRs) selected during thymopoiesis form a repertoire of about 10<sup>8</sup> unique TCRs per individual. How these diverse TCRs can effectively handle a countless and evolving set of infectious agents is a central question of immunology. The paradigm is that a diverse enough repertoire of TCRs should always provide a proper, though rare, specificity for any given need. We analy...

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Literature Corpus work: 8ebc2a7d-26e5-5b18-b203-47c8a67cf779
DOI: 10.2139/ssrn.3745929

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