Article

Epstein Barr virus epitope/MHC interaction combined with convergent recombination drive selection of diverse T cell receptor α and β repertoires

2020-02-07

Abstract excerpt

Recognition modes of individual T cell receptors (TCR) are well studied, but factors driving the selection of TCR repertoires from primary through persistent human virus infections are less well understood. Using deep sequencing, we demonstrate a high degree of diversity of EBV-specific clonotypes in acute infectious mononucleosis. Only 9% of unique clonotypes detected in AIM persisted into convalescence; the majo...

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Literature Corpus work: 0038b640-cac4-54df-a79a-e95b650a2545
DOI: 10.1101/2020.02.06.938241

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