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Article

Human thymic T cell repertoire is imprinted with strong convergence to shared sequences.

Molecular immunology - 1 Nov 2020

Heikkilä Nelli, Vanhanen Reetta, Yohannes Dawit A, Kleino Iivari, Mattila Ilkka P, Saramäki Jari, Arstila T Petteri

Abstract excerpt

A highly diverse repertoire of T cell antigen receptors (TCR) is created in the thymus by recombination of gene segments and the insertion or deletion of nucleotides at the junctions. Using next-generation TCR sequencing we define here the features of recombination and selection in the human TCRα and TCRβ locus, and show that a strikingly high proportion of the repertoire is shared by unrelated individuals. The...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell, alpha-beta

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Source

Identifiers

PMID: 32961421
DOI: 10.1016/j.molimm.2020.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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