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Article

BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia

7 May 2022

Abstract excerpt

BACKGROUND: The BIN1 locus contains the second-most significant genetic risk factor for late-onset Alzheimer's disease. BIN1 undergoes alternate splicing to generate tissue- and cell-type-specific BIN1 isoforms, which regulate membrane dynamics in a range of crucial cellular processes. Whilst the expression of BIN1 in the brain has been characterized in neurons and oligodendrocytes in detail, information...

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PMID: 35526014
DOI: 10.1186/s13024-022-00535-x

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