Article

IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer’s disease

2024-03-13

Abstract excerpt

<h4>Summary</h4> The pathological role of interferon signaling is emerging in neuroinflammatory disorders, yet, the specific role of Interferon Regulatory Factor 3 (IRF3) in neuroinflammation remains poorly understood. Here, we show that global IRF3 deficiency delays TLR4-mediated signaling in microglia and attenuates the hallmark features of LPS-induced inflammation such as cytokine release, microglial reactivit...

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Literature Corpus work: 824e7329-00ce-5e9c-9aa6-cb568e87ead9
DOI: 10.1101/2024.03.08.582968

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