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A large-scale transcriptome-wide association study (TWAS) of ten blood cell phenotypes reveals complexities of TWAS fine-mapping

2021-02-23

Abstract excerpt

Hematological measures are important intermediate clinical phenotypes for many acute and chronic diseases. Hematological measures are highly heritable, and although genome-wide association studies (GWAS) have identified thousands of loci containing trait-associated variants, the causal genes underlying these associations are often uncertain. To better understand the underlying genetic regulatory mechanisms, we per...

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Literature Corpus work: 3309b338-e94f-56aa-91d8-753a76cf4a6f
DOI: 10.1101/2021.02.23.432444

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