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Transcriptome-wide association study in UK Biobank Europeans identifies associations with blood cell traits.

Human molecular genetics - 21 Jul 2022

Rowland Bryce, Venkatesh Sanan, Tardaguila Manuel, Wen Jia, Rosen Jonathan D, Tapia Amanda L, Sun Quan, Graff Mariaelisa, Vuckovic Dragana, Lettre Guillaume, Sankaran Vijay G, Voloudakis Georgios, Roussos Panos, Huffman Jennifer E, Reiner Alexander P, Soranzo Nicole, Raffield Laura M, Li Yun

Abstract excerpt

Previous genome-wide association studies (GWAS) of hematological traits have identified over 10 000 distinct trait-specific risk loci. However, at these loci, the underlying causal mechanisms remain incompletely characterized. To elucidate novel biology and better understand causal mechanisms at known loci, we performed a transcriptome-wide association study (TWAS) of 29 hematological traits in 399 835 UK Biobank...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35138379
DOI: 10.1093/hmg/ddac011
PMCID: PMC9307312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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