Article

Multi-ancestry fine-mapping improves precision to identify causal genes in transcriptome-wide association studies

2022-02-11

Abstract excerpt

Transcriptome-wide association studies (TWAS) are a powerful approach to identify genes whose expression associates with complex disease risk. However, non-causal genes can exhibit association signals due to confounding by linkage disequilibrium patterns (LD) and eQTL pleiotropy at genomic risk regions which necessitates fine-mapping of TWAS signals. Here, we present MA-FOCUS, a multi-ancestry framework for the im...

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Literature Corpus work: 3d5e3df1-3512-5b2d-b31f-d026c161fc7c
DOI: 10.1101/2022.02.10.479993

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