Article
A large-scale transcriptome-wide association study (TWAS) of 10 blood cell phenotypes reveals complexities of TWAS fine-mapping.
Genetic epidemiology - 1 Feb 2022
Tapia Amanda L, Rowland Bryce T, Rosen Jonathan D, Preuss Michael, Young Kris, Graff Misa, Choquet Hélène, Couper David J, Buyske Steve, Bien Stephanie A, Jorgenson Eric, Kooperberg Charles, Loos Ruth J F, Morrison Alanna C, North Kari E, Yu Bing, Reiner Alexander P, Li Yun, Raffield Laura M
Abstract excerpt
Hematological measures are important intermediate clinical phenotypes for many acute and chronic diseases and are highly heritable. Although genome-wide association studies (GWAS) have identified thousands of loci containing trait-associated variants, the causal genes underlying these associations are often uncertain. To better understand the underlying genetic regulatory mechanisms, we performed a...
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